Difficulties in diagnosis and options for endoscopic treatment of esophageal granular cell tumors
https://doi.org/10.31146/2415-7813-endo-68-1-20-26
Abstract
Granular cell tumor is a rare mesenchymal neoplasm of neurogenic origin. The clinical course of GCT is mostly asymptomatic. In the gastrointestinal tract, it usually presents as a submucosal lesion detected during routine endoscopic examination. The article presents the experience of managing patients at the GBUZ Moscow Clinical Scientific Center named after Loginov MHD from 2017 to 2025.
About the Authors
E. A. Grishina
Moscow Clinical Scientific and Practical Center named after A.S. Loginov of the Department of Healthcare of the City of Moscow
Russian Federation
Russian Federation
K. V. Shishin
Moscow Clinical Scientific and Practical Center named after A.S. Loginov of the Department of Healthcare of the City of Moscow
Russian Federation
Russian Federation
I. Yu. Nedoluzhko
Moscow Clinical Scientific and Practical Center named after A.S. Loginov of the Department of Healthcare of the City of Moscow
Russian Federation
Russian Federation
I. S. Kanishchev
Moscow Clinical Scientific and Practical Center named after A.S. Loginov of the Department of Healthcare of the City of Moscow
Russian Federation
Russian Federation
N. S. Karnaukhov
Moscow Clinical Scientific and Practical Center named after A.S. Loginov of the Department of Healthcare of the City of Moscow
Russian Federation
Russian Federation
References
1. Radaelli F., Minoli G. Granular Cell Tumors of the Gastrointestinal Tract: Questions and Answers. Gastroenterol Hepatol (N Y). 2009 Nov;5(11):798-800. PMID: 37967389
2. Canavesi A., Berrueta J., Pillajo S., Gaggero P., Olano C. Endoscopic resection of a granular cell tumor (Abrikossoff’s tumor) in the esophagus using cap-assisted band ligation. Endoscopy. 2023 Dec;55(S 01): E796-E797. doi: 10.1055/a-2088-1849.
3. Nakajima M., Kato H., Muroi H. et al. Esophageal granular cell tumor successfully resected by endoscopic submucosal dissection. Esophagus. 2011;8:203-207. doi: 10.1007/s10388-011-0283-7.
4. Kneitz H., Frings V., Kircher S., Goebeler M. Expression of Connexin 43 in Granular Cell Tumors of the Skin, Tongue and Esophagus. Dermatopathology (Basel). 2023 Jun 16;10(2):184-192. doi: 10.3390/dermatopathology10020026.
5. Singhi A.D., Montgomery E.A. Colorectal granular cell tumor: a clinicopathologic study of 26 cases. Am J Surg Pathol. 2010 Aug;34(8):1186-92. doi: 10.1097/PAS.0b013e3181e5af9d.
6. Ryu D.G., Choi C.W., Kim S.J. et al. Clinical outcomes of esophageal granular cell tumors with different endoscopic resection methods. Sci Rep. 2023 Jul 3;13(1):10738. doi: 10.1038/s41598-023-37998-x.
7. Kim D.U., Kim G.H., Ryu D.Y. et al. Endosonographic features of esophageal granular cell tumors using a high-frequency catheter probe. Scand J Gastroenterol. 2011 Feb;46(2):142-7. doi: 10.3109/00365521.2010.525661.
8. Tipirneni K., Mehl A., Bowman B, Joshi V. Esophageal Granular Cell Tumor: A Benign Tumor or an Insidious Cause for Concern? Ochsner J. 2016 Winter;16(4):558-561. PMID: 27999519.
9. Lim T.W., Choi C.W., Kang D.H., Kim H.W., Park S.B., Kim S.J.Endoscopic ultrasound without tissue acquisition has poor accuracy for diagnosing gastric subepithelial tumors. Medicine (Baltimore). 2016 Nov;95(44): e5246. doi: 10.1097/MD.0000000000005246.
10. Shao C., Chen K., Duan Y., Xu J. Case Report: A large granular cell tumor of the cervical esophagus with single cell RNA sequencing analysis. Front Oncol. 2025 Sep 2;15:1580121. doi: 10.3389/fonc.2025.1580121.
11. Battaglia G., Rampado S., Bocus P., Guido E., Portale G., Ancona E. Single-band mucosectomy for granular cell tumor of the esophagus: safe and easy technique. Surg Endosc. 2006 Aug;20(8):1296-8. doi: 10.1007/s00464-005-0638-z.
Review
For citations:
Grishina E.A., Shishin K.V., Nedoluzhko I.Yu., Kanishchev I.S., Karnaukhov N.S. Difficulties in diagnosis and options for endoscopic treatment of esophageal granular cell tumors. Filin’s Clinical endoscopy. 2026;68(1):20-26. (In Russ.) https://doi.org/10.31146/2415-7813-endo-68-1-20-26
Views:
26
JATS XML
Email this article 