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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinendo</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая эндоскопия</journal-title><trans-title-group xml:lang="en"><trans-title>Filin’s Clinical endoscopy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2415-7813</issn><publisher><publisher-name>"Global Media technology" Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/2415-7813-endo-68-1-20-26</article-id><article-id custom-type="elpub" pub-id-type="custom">clinendo-688</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГАСТРОЭНТЕРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GASTROENTEROLOGY</subject></subj-group></article-categories><title-group><article-title>Сложности диагностики и варианты эндоскопического лечения гранулярно-клеточных опухолей пищевода</article-title><trans-title-group xml:lang="en"><trans-title>Difficulties in diagnosis and options for endoscopic treatment of esophageal granular cell tumors</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1265-8382</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гришина</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Grishina</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">marginis@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0010-5294</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шишин</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shishin</surname><given-names>K. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2647-4362</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Недолужко</surname><given-names>И. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Nedoluzhko</surname><given-names>I. Yu.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2175-4621</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Канищев</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kanishchev</surname><given-names>I. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0889-2720</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карнаухов</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Karnaukhov</surname><given-names>N. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Государственное бюджетное учреждение здравоохранения города Москвы "Московский Клинический Научно-практический Центр имени А.С. Логинова Департамента здравоохранения города Москвы"</institution></aff><aff xml:lang="en"><institution>Moscow Clinical Scientific and Practical Center named after A.S. Loginov of the Department of Healthcare of the City of Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>22</day><month>04</month><year>2026</year></pub-date><volume>68</volume><issue>1</issue><fpage>20</fpage><lpage>26</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гришина Е.А., Шишин К.В., Недолужко И.Ю., Канищев И.С., Карнаухов Н.С., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Гришина Е.А., Шишин К.В., Недолужко И.Ю., Канищев И.С., Карнаухов Н.С.</copyright-holder><copyright-holder xml:lang="en">Grishina E.A., Shishin K.V., Nedoluzhko I.Y., Kanishchev I.S., Karnaukhov N.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://clinendo.elpub.ru/jour/article/view/688">https://clinendo.elpub.ru/jour/article/view/688</self-uri><abstract><p>Гранулярно-клеточная опухоль (ГКО) представляет собой редкое мезенхимальное новообразование нейрогенного происхождения. Клиническое течение ГКО в большинстве случаев бессимптомное. В желудочно-кишечном тракте она обычно проявляется как подслизистое образование, обнаруживаемое при плановом эндоскопическом исследовании. В статье представлен опыт ведения пациентов МКНЦ имени А.С. Логинова в период с 2017 по 2025 год.</p></abstract><trans-abstract xml:lang="en"><p>Granular cell tumor is a rare mesenchymal neoplasm of neurogenic origin. The clinical course of GCT is mostly asymptomatic. In the gastrointestinal tract, it usually presents as a submucosal lesion detected during routine endoscopic examination. The article presents the experience of managing patients at the GBUZ Moscow Clinical Scientific Center named after Loginov MHD from 2017 to 2025.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>эндоскопия</kwd><kwd>гранулярно-клеточные опухоли</kwd><kwd>ЭУС</kwd><kwd>эндоскопическое удаление новообразований</kwd></kwd-group><kwd-group xml:lang="en"><kwd>endoscopy</kwd><kwd>granular cell tumors</kwd><kwd>EUS</kwd><kwd>endoscopic resection of neoplasms</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Radaelli F., Minoli G. Granular Cell Tumors of the Gastrointestinal Tract: Questions and Answers. Gastroenterol Hepatol (N Y). 2009 Nov;5(11):798-800. PMID: 37967389</mixed-citation><mixed-citation xml:lang="en">Radaelli F., Minoli G. Granular Cell Tumors of the Gastrointestinal Tract: Questions and Answers. Gastroenterol Hepatol (N Y). 2009 Nov;5(11):798-800. PMID: 37967389</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Canavesi A., Berrueta J., Pillajo S., Gaggero P., Olano C. Endoscopic resection of a granular cell tumor (Abrikossoff’s tumor) in the esophagus using cap-assisted band ligation. Endoscopy. 2023 Dec;55(S 01): E796-E797. doi: 10.1055/a-2088-1849.</mixed-citation><mixed-citation xml:lang="en">Canavesi A., Berrueta J., Pillajo S., Gaggero P., Olano C. Endoscopic resection of a granular cell tumor (Abrikossoff’s tumor) in the esophagus using cap-assisted band ligation. Endoscopy. 2023 Dec;55(S 01): E796-E797. doi: 10.1055/a-2088-1849.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Nakajima M., Kato H., Muroi H. et al. Esophageal granular cell tumor successfully resected by endoscopic submucosal dissection. Esophagus. 2011;8:203-207. doi: 10.1007/s10388-011-0283-7.</mixed-citation><mixed-citation xml:lang="en">Nakajima M., Kato H., Muroi H. et al. Esophageal granular cell tumor successfully resected by endoscopic submucosal dissection. Esophagus. 2011;8:203-207. doi: 10.1007/s10388-011-0283-7.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kneitz H., Frings V., Kircher S., Goebeler M. Expression of Connexin 43 in Granular Cell Tumors of the Skin, Tongue and Esophagus. Dermatopathology (Basel). 2023 Jun 16;10(2):184-192. doi: 10.3390/dermatopathology10020026.</mixed-citation><mixed-citation xml:lang="en">Kneitz H., Frings V., Kircher S., Goebeler M. Expression of Connexin 43 in Granular Cell Tumors of the Skin, Tongue and Esophagus. Dermatopathology (Basel). 2023 Jun 16;10(2):184-192. doi: 10.3390/dermatopathology10020026.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Singhi A.D., Montgomery E.A. Colorectal granular cell tumor: a clinicopathologic study of 26 cases. Am J Surg Pathol. 2010 Aug;34(8):1186-92. doi: 10.1097/PAS.0b013e3181e5af9d.</mixed-citation><mixed-citation xml:lang="en">Singhi A.D., Montgomery E.A. Colorectal granular cell tumor: a clinicopathologic study of 26 cases. Am J Surg Pathol. 2010 Aug;34(8):1186-92. doi: 10.1097/PAS.0b013e3181e5af9d.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ryu D.G., Choi C.W., Kim S.J. et al. Clinical outcomes of esophageal granular cell tumors with different endoscopic resection methods. Sci Rep. 2023 Jul 3;13(1):10738. doi: 10.1038/s41598-023-37998-x.</mixed-citation><mixed-citation xml:lang="en">Ryu D.G., Choi C.W., Kim S.J. et al. Clinical outcomes of esophageal granular cell tumors with different endoscopic resection methods. Sci Rep. 2023 Jul 3;13(1):10738. doi: 10.1038/s41598-023-37998-x.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kim D.U., Kim G.H., Ryu D.Y. et al. Endosonographic features of esophageal granular cell tumors using a high-frequency catheter probe. Scand J Gastroenterol. 2011 Feb;46(2):142-7. doi: 10.3109/00365521.2010.525661.</mixed-citation><mixed-citation xml:lang="en">Kim D.U., Kim G.H., Ryu D.Y. et al. Endosonographic features of esophageal granular cell tumors using a high-frequency catheter probe. Scand J Gastroenterol. 2011 Feb;46(2):142-7. doi: 10.3109/00365521.2010.525661.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Tipirneni K., Mehl A., Bowman B, Joshi V. Esophageal Granular Cell Tumor: A Benign Tumor or an Insidious Cause for Concern? Ochsner J. 2016 Winter;16(4):558-561. PMID: 27999519.</mixed-citation><mixed-citation xml:lang="en">Tipirneni K., Mehl A., Bowman B, Joshi V. Esophageal Granular Cell Tumor: A Benign Tumor or an Insidious Cause for Concern? Ochsner J. 2016 Winter;16(4):558-561. PMID: 27999519.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Lim T.W., Choi C.W., Kang D.H., Kim H.W., Park S.B., Kim S.J.Endoscopic ultrasound without tissue acquisition has poor accuracy for diagnosing gastric subepithelial tumors. Medicine (Baltimore). 2016 Nov;95(44): e5246. doi: 10.1097/MD.0000000000005246.</mixed-citation><mixed-citation xml:lang="en">Lim T.W., Choi C.W., Kang D.H., Kim H.W., Park S.B., Kim S.J.Endoscopic ultrasound without tissue acquisition has poor accuracy for diagnosing gastric subepithelial tumors. Medicine (Baltimore). 2016 Nov;95(44): e5246. doi: 10.1097/MD.0000000000005246.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Shao C., Chen K., Duan Y., Xu J. Case Report: A large granular cell tumor of the cervical esophagus with single cell RNA sequencing analysis. Front Oncol. 2025 Sep 2;15:1580121. doi: 10.3389/fonc.2025.1580121.</mixed-citation><mixed-citation xml:lang="en">Shao C., Chen K., Duan Y., Xu J. Case Report: A large granular cell tumor of the cervical esophagus with single cell RNA sequencing analysis. Front Oncol. 2025 Sep 2;15:1580121. doi: 10.3389/fonc.2025.1580121.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Battaglia G., Rampado S., Bocus P., Guido E., Portale G., Ancona E. Single-band mucosectomy for granular cell tumor of the esophagus: safe and easy technique. Surg Endosc. 2006 Aug;20(8):1296-8. doi: 10.1007/s00464-005-0638-z.</mixed-citation><mixed-citation xml:lang="en">Battaglia G., Rampado S., Bocus P., Guido E., Portale G., Ancona E. Single-band mucosectomy for granular cell tumor of the esophagus: safe and easy technique. Surg Endosc. 2006 Aug;20(8):1296-8. doi: 10.1007/s00464-005-0638-z.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
