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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinendo</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая эндоскопия</journal-title><trans-title-group xml:lang="en"><trans-title>Filin’s Clinical endoscopy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2415-7813</issn><publisher><publisher-name>"Global Media technology" Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/2415-7813-endo-68-2-36-39</article-id><article-id custom-type="elpub" pub-id-type="custom">clinendo-710</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГАСТРОЭНТЕРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GASTROENTEROLOGY</subject></subj-group></article-categories><title-group><article-title>Особенности поражения верхних отделов желудочно-кишечного тракта во время дебюта болезни Крона</article-title><trans-title-group xml:lang="en"><trans-title>Features of upper gastrointestinal involvement during the onset of Crohn’s disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4461-4322</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трапезникова</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Trapeznikova</surname><given-names>A. Yu.</given-names></name></name-alternatives><email xlink:type="simple">anka.solomaha@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-7103-6468</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пермякова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Permyakova</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1515-3523</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильева</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilyeva</surname><given-names>A. G.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-9553-8635</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коростовцева</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Korostovtseva</surname><given-names>E. Yu.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-3168-5012</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванов</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanov</surname><given-names>G. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России</institution></aff><aff xml:lang="en"><institution>Saint-Petersburg State Pediatric Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России; ЛОГБУЗ «Детская клиническая больница»</institution></aff><aff xml:lang="en"><institution>Saint-Petersburg State Pediatric Medical University; Leningrad regional state budgetary institution of health «Children’s Clinical Hospital»</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ЛОГБУЗ «Детская клиническая больница»</institution></aff><aff xml:lang="en"><institution>Leningrad regional state budgetary institution of health «Children’s Clinical Hospital»</institution></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Университетская клиника Шлезвиг-Гольштейн</institution></aff><aff xml:lang="en"><institution>University Hospital Schleswig-Holstein (UKSH)</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>23</day><month>04</month><year>2026</year></pub-date><volume>68</volume><issue>2</issue><fpage>36</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Трапезникова А.Ю., Пермякова А.А., Васильева А.Г., Коростовцева Е.Ю., Иванов Г.В., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Трапезникова А.Ю., Пермякова А.А., Васильева А.Г., Коростовцева Е.Ю., Иванов Г.В.</copyright-holder><copyright-holder xml:lang="en">Trapeznikova A.Y., Permyakova A.A., Vasilyeva A.G., Korostovtseva E.Y., Ivanov G.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://clinendo.elpub.ru/jour/article/view/710">https://clinendo.elpub.ru/jour/article/view/710</self-uri><abstract><p>Болезнь Крона (БК) - это многофакторное воспалительное заболевание, при котором может поражаться любой отдел желудочно-кишечного тракта (ЖКТ), однако обычно патологический процесс затрагивает подвздошную кишку и/или толстую кишку. Для оценки прогноза заболевания у пациента и подбора подходящей схемы терапии необходимо точно оценить факторы, влияющие на отрицательные результаты, включая фенотип болезни. В последнее время с внедрением обязательного проведения эндоскопического исследования верхних отделов ЖКТ при подозрении на болезнь Крона, диагностика поражений органов этой локализации стала чаще встречаться и описываться в литературе. Большинство клинических проявлений поражения пищевода, желудка или двенадцатиперстной кишки (ДПК) являются неспецифическими и требуют морфологической верификации диагноза, поскольку могут протекать под маской обычного гастрита или дуоденита. Описана и доказана связь с БК таких поражений как афтоидные язвы, симптом перетяжек по типу «бамбука» слизистой желудка, формирование стеноза и свища выходного отдела желудка. Кроме того, гистологические данные, такие как выраженная очаговая эритематозная гастропатия и несосудистые гранулемы, могут наводить на мысль о БК. Связь между вовлечением верхних отделов ЖКТ и неблагоприятным прогнозом при болезни Крона остается спорной. В настоящее время отсутствуют критерии оценки тяжести поражения и понимания степени участия верхних отделов ЖКТ при БК для долгосрочного прогноза заболевания. В данной статье представлены собственные данные обследования детей и клинический случай поражения желудка и ДПК во время дебюта болезни Крона.</p></abstract><trans-abstract xml:lang="en"><p>Crohn’s disease (CD) is a multifactorial inflammatory disease in which any part of the gastrointestinal tract can be affected, however, it usually affects the ileum and/or colon. In order to assess the prognosis of the patient and the selection of an appropriate therapy regimen, it is necessary to accurately assess the factors affecting negative results, including the disease phenotype. Recently, with the introduction of mandatory endoscopic examination of the upper gastrointestinal tract (UGI) with suspected Crohn’s disease, diagnosis of organ lesions of this localization has become more common and described in the literature. Most of the clinical manifestations of esophageal, gastric or duodenal lesions are nonspecific and require morphological verification of the diagnosis, since they can occur under the guise of ordinary gastritis or duodenitis. In addition, histological findings such as marked focal erythematous gastropathy and non-vascular granulomas may be suggestive of CD. The association between upper UGI involvement and poor prognosis in Crohn’s disease remains controversial. Currently, there are no criteria for assessing the severity of the lesion and understanding the degree of participation of the upper gastrointestinal tract in CD for the long-term prognosis of the disease. This article presents the children’s own examination data and a clinical case of gastric and duodenal involvement at the onset of Crohn’s disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>болезнь Крона</kwd><kwd>гастрит</kwd><kwd>дуоденит</kwd><kwd>дети</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Crohn’s disease</kwd><kwd>gastritis</kwd><kwd>duodenitis</kwd><kwd>children</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Baumgart D.C., Sandborn W.J. Crohn’s disease. Lancet. 2012 Nov 3;380(9853):1590-605. doi: 10.1016/S0140-6736(12)60026-9.</mixed-citation><mixed-citation xml:lang="en">Baumgart D.C., Sandborn W.J. Crohn’s disease. Lancet. 2012 Nov 3;380(9853):1590-605. doi: 10.1016/S0140-6736(12)60026-9.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Khavkin A.I., Novikova V.P., Trapeznikova A. Yu., Yablokova E.A., Erokhina M.I., Chibrina E.V. Voprosy dietologii. 2023;13(1):30-35. (in Russ.) doi: 10.20953/2224-5448-2023-1-30-35.@@ Хавкин А.И., Новикова В.П., Трапезникова А.Ю., Яблокова Е.А., Ерохина М.И., Чибрина Е.В. Воспалительные заболевания кишечника и гельминтозы. Вопросы диетологии. 2023;13(1):30-35. doi: 10.20953/2224-5448-2023-1-30-35.</mixed-citation><mixed-citation xml:lang="en">Khavkin A.I., Novikova V.P., Trapeznikova A. Yu., Yablokova E.A., Erokhina M.I., Chibrina E.V. Voprosy dietologii. 2023;13(1):30-35. (in Russ.) doi: 10.20953/2224-5448-2023-1-30-35.@@ Хавкин А.И., Новикова В.П., Трапезникова А.Ю., Яблокова Е.А., Ерохина М.И., Чибрина Е.В. Воспалительные заболевания кишечника и гельминтозы. Вопросы диетологии. 2023;13(1):30-35. doi: 10.20953/2224-5448-2023-1-30-35.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ghione S., Sarter H., Fumery M., Armengol-Debeir L., Savoye G., Ley D. et al. Dramatic increase in incidence of ulcerative colitis and Crohn’s disease (1988-2011): a population-based study of French adolescents. Am J Gastroenterol. 2018;113:265-72. doi: 10.1038/ajg.2017.228.</mixed-citation><mixed-citation xml:lang="en">Ghione S., Sarter H., Fumery M., Armengol-Debeir L., Savoye G., Ley D. et al. Dramatic increase in incidence of ulcerative colitis and Crohn’s disease (1988-2011): a population-based study of French adolescents. Am J Gastroenterol. 2018;113:265-72. doi: 10.1038/ajg.2017.228.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Novikova V.P., Matalygina O.A., Gurova M.M. et al. Semiotics and syndromes of digestive system damage in children. Textbook for 3rd-year students of the pediatric faculty. Series: Library of the Pediatric University. St. Petersburg, 2022. (in Russ.)@@ Новикова В.П., Маталыгина О.А., Гурова М.М. и др. Семиотика и синдромы поражения пищеварительной системы у детей. Учебно-методическое пособие для студентов 3 курса педиатрического факультета. Сер. Библиотека педиатрического университета. Санкт-Петерург, 2022.</mixed-citation><mixed-citation xml:lang="en">Novikova V.P., Matalygina O.A., Gurova M.M. et al. Semiotics and syndromes of digestive system damage in children. Textbook for 3rd-year students of the pediatric faculty. Series: Library of the Pediatric University. St. Petersburg, 2022. (in Russ.)@@ Новикова В.П., Маталыгина О.А., Гурова М.М. и др. Семиотика и синдромы поражения пищеварительной системы у детей. Учебно-методическое пособие для студентов 3 курса педиатрического факультета. Сер. Библиотека педиатрического университета. Санкт-Петерург, 2022.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Benchimol E.I., Fortinsky K.J., Gozdyra P., Van den Heuvel M., Van Limbergen J., Griffiths A.M. Epidemiology of pediatric inflammatory bowel disease: a systematic review of international trends. Inflamm Bowel Dis. 2011 Jan;17(1):423-39. doi: 10.1002/ibd.21349.</mixed-citation><mixed-citation xml:lang="en">Benchimol E.I., Fortinsky K.J., Gozdyra P., Van den Heuvel M., Van Limbergen J., Griffiths A.M. Epidemiology of pediatric inflammatory bowel disease: a systematic review of international trends. Inflamm Bowel Dis. 2011 Jan;17(1):423-39. doi: 10.1002/ibd.21349.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Satsangi J., Silverberg M.S., Vermeire S., Colombel J.F. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut. 2006 Jun;55(6):749-53. doi: 10.1136/gut.2005.082909.</mixed-citation><mixed-citation xml:lang="en">Satsangi J., Silverberg M.S., Vermeire S., Colombel J.F. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut. 2006 Jun;55(6):749-53. doi: 10.1136/gut.2005.082909.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Levine A., Griffiths A., Markowitz J. et al. Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification. Inflamm Bowel Dis. 2011;17:131421. doi: 10.1002/ibd.21493.</mixed-citation><mixed-citation xml:lang="en">Levine A., Griffiths A., Markowitz J. et al. Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification. Inflamm Bowel Dis. 2011;17:131421. doi: 10.1002/ibd.21493.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Van Hogezand R.A., Witte A.M., Veenendaal R.A., Wagtmans M.J., Lamers C.B. Proximal Crohn’s disease: review of the clinicopathologic features and therapy. Inflamm Bowel Dis. 2001;7:328-37. doi: 10.1097/00054725-200111000-00010.</mixed-citation><mixed-citation xml:lang="en">Van Hogezand R.A., Witte A.M., Veenendaal R.A., Wagtmans M.J., Lamers C.B. Proximal Crohn’s disease: review of the clinicopathologic features and therapy. Inflamm Bowel Dis. 2001;7:328-37. doi: 10.1097/00054725-200111000-00010.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Laube R., Liu K., Schifter M., Yang J.L., Suen M.K., Leong R.W. Oral and upper gastrointestinal Crohn’s disease. J Gastroenterol Hepatol. 2018;33:355-64. doi: 10.1111/jgh.13866.</mixed-citation><mixed-citation xml:lang="en">Laube R., Liu K., Schifter M., Yang J.L., Suen M.K., Leong R.W. Oral and upper gastrointestinal Crohn’s disease. J Gastroenterol Hepatol. 2018;33:355-64. doi: 10.1111/jgh.13866.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Yamamoto T., Allan R.N., Keighley M.R. An audit of gastroduodenal Crohn disease: clinicopathologic features and management. Scand J Gastroenterol. 1999;34:1019-24. doi: 10.1080/003655299750025138.</mixed-citation><mixed-citation xml:lang="en">Yamamoto T., Allan R.N., Keighley M.R. An audit of gastroduodenal Crohn disease: clinicopathologic features and management. Scand J Gastroenterol. 1999;34:1019-24. doi: 10.1080/003655299750025138.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Wang W., Ni Y., Ke C., Cheng Q., Lu Q., Li X. Isolated Crohn’s disease of the esophagus with esophago-mediastinal fistula formation. World J Surg Oncol. 2012;10:208. doi: 10.1186/1477-7819-10-208.</mixed-citation><mixed-citation xml:lang="en">Wang W., Ni Y., Ke C., Cheng Q., Lu Q., Li X. Isolated Crohn’s disease of the esophagus with esophago-mediastinal fistula formation. World J Surg Oncol. 2012;10:208. doi: 10.1186/1477-7819-10-208.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Wagtmans M.J., Verspaget H.W., Lamers C.B., van Hogezand R.A. Clinical aspects of Crohn’s disease of the upper gastrointestinal tract: a comparison with distal Crohn’s disease. Am J Gastroenterol. 1997 Sep;92(9):1467-71.</mixed-citation><mixed-citation xml:lang="en">Wagtmans M.J., Verspaget H.W., Lamers C.B., van Hogezand R.A. Clinical aspects of Crohn’s disease of the upper gastrointestinal tract: a comparison with distal Crohn’s disease. Am J Gastroenterol. 1997 Sep;92(9):1467-71.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Mottet C., Juillerat P., Pittet V. et al. Upper gastrointestinal Crohn’s disease. Digestion. 2007;76(2):136-40. doi: 10.1159/000111028.</mixed-citation><mixed-citation xml:lang="en">Mottet C., Juillerat P., Pittet V. et al. Upper gastrointestinal Crohn’s disease. Digestion. 2007;76(2):136-40. doi: 10.1159/000111028.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Khalilova N.A., Trapeznikova A. Yu., Shestakova M.D. Iron deficiency anemia in the structure of chronic diseases (literature review). Children’s Medicine of the North-West. 2023;11(3):68-75. (in Russ.) doi: 10.56871/CmN-W.2023.79.81.004 2012.@@ Халилова Н.А., Трапезникова А.Ю., Шестакова М.Д. Железодефицитная анемия в структуре хронических заболеваний (обзор литературы). Children’s Medicine of the North-West. 2023;11(3):68-75. doi: 10.56871/CmN-W.2023.79.81.004 2012.</mixed-citation><mixed-citation xml:lang="en">Khalilova N.A., Trapeznikova A. Yu., Shestakova M.D. Iron deficiency anemia in the structure of chronic diseases (literature review). Children’s Medicine of the North-West. 2023;11(3):68-75. (in Russ.) doi: 10.56871/CmN-W.2023.79.81.004 2012.@@ Халилова Н.А., Трапезникова А.Ю., Шестакова М.Д. Железодефицитная анемия в структуре хронических заболеваний (обзор литературы). Children’s Medicine of the North-West. 2023;11(3):68-75. doi: 10.56871/CmN-W.2023.79.81.004 2012.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
