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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinendo</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая эндоскопия</journal-title><trans-title-group xml:lang="en"><trans-title>Filin’s Clinical endoscopy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2415-7813</issn><publisher><publisher-name>"Global Media technology" Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/2415-7813-endo-68-1-27-30</article-id><article-id custom-type="elpub" pub-id-type="custom">clinendo-689</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГАСТРОЭНТЕРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GASTROENTEROLOGY</subject></subj-group></article-categories><title-group><article-title>Эндоскопическое комбинированное удаление тубуло-ворсинчатой опухоли нисходящей части двенадцатиперстной кишки</article-title><trans-title-group xml:lang="en"><trans-title>Endoscopic combined removal of tubulovillous tumor of the descending duodenum</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4324-4470</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каммаев</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kammaev</surname><given-names>K. A.</given-names></name></name-alternatives><email xlink:type="simple">kerim.kammaev95@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-0406-3510</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рахманов</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Rahmanov</surname><given-names>V. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-7890-7759</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рамазанова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ramazanova</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-5073-4232</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шакарова</surname><given-names>Л. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Shakarova</surname><given-names>L. R.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное автономное образовательное учреждение высшего образования Первый Московский государственный медицинский университет имени И.М. Сеченова Министерства здравоохранения Российской Федерации (Сеченовский Университет)</institution></aff><aff xml:lang="en"><institution>Sechenov University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>22</day><month>04</month><year>2026</year></pub-date><volume>68</volume><issue>1</issue><fpage>27</fpage><lpage>30</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Каммаев К.А., Рахманов В.Н., Рамазанова А.А., Шакарова Л.Р., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Каммаев К.А., Рахманов В.Н., Рамазанова А.А., Шакарова Л.Р.</copyright-holder><copyright-holder xml:lang="en">Kammaev K.A., Rahmanov V.N., Ramazanova A.A., Shakarova L.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://clinendo.elpub.ru/jour/article/view/689">https://clinendo.elpub.ru/jour/article/view/689</self-uri><abstract><p>Опухоли двенадцатиперстной кишки (ДПК) относятся к редким новообразованиям желудочно-кишечного тракта и характеризуются значительной клинико-патологической гетерогенностью. В зависимости от фенотипа муцина выделяют кишечный и желудочный типы опухолевых поражений, отличающиеся по локализации, рискам подслизистой инвазии и лимфогенного метастазирования. Наиболее частым злокачественным новообразованием ДПК является аденокарцинома, при этом опухоли преимущественно локализуются в нисходящей части кишки. Выбор лечебной тактики зависит от размеров образования, глубины инвазии и вовлечённости сосудистых структур, при этом эндоскопические методы удаления широко применяются на ранних стадиях заболевания Цель: демонстрация возможностей комбинированного эндоскопического подхода (EMR и ESD) при удалении неампулярной тубуло-ворсинчатой опухоли нисходящей части ДПК. Материалы и методы: представлен клинический случай пациентки 67 лет с эпителиальным образованием нисходящей части ДПК размерами до 30 мм, выявленным при эзофагогастродуоденоскопии. По данным лучевых методов обследования признаков трансмурального роста не выявлено. Первоначально выполнена подслизистая диссекция, осложнившаяся интраоперационным кровотечением, в связи с чем тактика была изменена на эндоскопическую резекцию слизистой оболочки. Результаты: Опухоль удалена фрагментарно в пределах неизменённой слизистой оболочки. Удаление сопровождалось активным кровотечением. гемостаз был успешно достигнут с использованием коагуляции, местного введения адреналина и системной гемостатической терапии. По данным патолого-анатомического исследования диагностирована тубуло-ворсинчатая аденома с очагами тяжёлой дисплазии эпителия. В послеоперационном периоде осложнений не отмечено, при контрольных эндоскопических исследованиях выявлена полная эпителизация зоны резекции.</p></abstract><trans-abstract xml:lang="en"><p>Duodenal tumors (duodenal tumors) are rare neoplasms of the gastrointestinal tract and are characterized by significant clinical and pathological heterogeneity. Depending on the phenotype of mucin, intestinal and gastric types of tumor lesions are distinguished, differing in localization, risks of submucosal invasion and lymphogenic metastasis. The most common malignant neoplasm of the duodenum is adenocarcinoma, with tumors predominantly localized in the descending intestine. The choice of therapeutic tactics depends on the size of the formation, the depth of invasion and the involvement of vascular structures, while endoscopic removal methods are widely used in the early stages of the disease. Objective: to demonstrate the possibilities of a combined endoscopic approach (EMR and ESD) for the removal of a nonampular tubulo-villous tumor of the descending part of the duodenum. Materials and methods: a clinical case of a 67-year-old patient with epithelial formation of the descending part of the duodenum up to 30 mm in size, revealed by esophagogastroduodenoscopy, is presented. According to the radiation examination methods, no signs of transmural growth were detected. Initially, submucosal dissection was performed, complicated by intraoperative bleeding, and therefore the tactics were changed to endoscopic resection of the mucous membrane. Results: The tumor was removed fragmentarily within the unchanged mucous membrane. The removal was accompanied by active bleeding. Hemostasis was successfully achieved using coagulation, local administration of epinephrine, and systemic hemostatic therapy. According to the pathological and anatomical examination, tubulo-villous adenoma with foci of severe epithelial dysplasia was diagnosed. No complications were noted in the postoperative period, and control endoscopic examinations revealed complete epithelialization of the resection area.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>неампулярные опухоли двенадцатиперстной кишки</kwd><kwd>тубуло-ворсинчатая аденома</kwd><kwd>аденома двенадцатиперстной кишки</kwd><kwd>эндоскопическая резекция слизистой (EMR)</kwd><kwd>эндоскопическая подслизистая диссекция (ESD)</kwd></kwd-group><kwd-group xml:lang="en"><kwd>nonampular tumors of the duodenum</kwd><kwd>tubulo-villous adenoma</kwd><kwd>duodenal adenoma</kwd><kwd>endoscopic mucosal resection (EMR)</kwd><kwd>endoscopic submucosal dissection (ESD)</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Goldner B., Stabile B.E. Duodenal adenocarcinoma: why the extreme rarity of duodenal bulb primary tumors? Am Surg. 2014 Oct;80(10):956-9. 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