clinendoКлиническая эндоскопияFilin’s Clinical endoscopy2415-7813"Global Media technology" Ltdclinendo-453Research ArticleОБЗОР ЛИТЕРАТУРЫАльтернативный путь развития колоректального рака. Эндоскопические и морфологические особенности зубчатых пораженийAlternative way of colorectal cancer developement. Endoscopic and morphological features os serrated lesionsАгейкинаН. В.AgeykinaN. V.noemail@neicon.ruДуванскийВ. А.DuvanskiyV. A.noemail@neicon.ruКнязевМ. В.KnyazevM. V.noemail@neicon.ruМальковП. Г.MaikovP. G.noemail@neicon.ruДаниловаН. В.DanilovaN. V.noemail@neicon.ruХарловаО. А.HarlovaO. V.noemail@neicon.ruФБЛПУ «Поликлиника №2 Минэкономразвития РФ»Polyclinic №2РУДНRUDNМГУ имени М.В. ЛомоносоваMocsow State University20140912202513849Copyright © Агейкина Н.В., Дуванский В.А., Князев М.В., Мальков П.Г., Данилова Н.В., Харлова О.А., 20252025Агейкина Н.В., Дуванский В.А., Князев М.В., Мальков П.Г., Данилова Н.В., Харлова О.А.Ageykina N.V., Duvanskiy V.A., Knyazev M.V., Maikov P.G., Danilova N.V., Harlova O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://clinendo.elpub.ru/jour/article/view/453ReferencesFearon E.R, Vogelstein В. A genetic model for colorectal tumorigenesis. Cell 1990;61(5):759-67Fearon E.R, Vogelstein В. A genetic model for colorectal tumorigenesis. Cell 1990;61(5):759-67Lu F.I, van Niekerk de W, Owen D, Tha S.P, Turbin D.A, Webber D.L. Longitudinal outcome study of sessile serrated adenomas of the colorectum: an increased risk for subsequent right-sided colorectal carcinoma. Am J SurgPathol. 2010;34(7):927-34Lu F.I, van Niekerk de W, Owen D, Tha S.P, Turbin D.A, Webber D.L. Longitudinal outcome study of sessile serrated adenomas of the colorectum: an increased risk for subsequent right-sided colorectal carcinoma. Am J SurgPathol. 2010;34(7):927-34Oono Y, Fu K, Nakamura H, Iriguchi Y, et al. Progression of a sessile serrated adenoma to an early invasive cancer within 8 months. Dig Dis Sci. 2009;54(4):906-9Oono Y, Fu K, Nakamura H, Iriguchi Y, et al. Progression of a sessile serrated adenoma to an early invasive cancer within 8 months. Dig Dis Sci. 2009;54(4):906-9Hawkins N, Bariol C, Ward R. The serrated neoplasia pathway. Pathology. 2002;34:548-555Hawkins N, Bariol C, Ward R. The serrated neoplasia pathway. Pathology. 2002;34:548-555Riddell R, Petras R, Williams G, et al. Tumors of the intestines. Washington, DC: Armed Forces Institute of Pathology. 2003Riddell R, Petras R, Williams G, et al. Tumors of the intestines. Washington, DC: Armed Forces Institute of Pathology. 2003Goldman H, Ming S, Hickcock D. Nature and significance of hyperplastic polyps of the human colon. ArchPathol 1970:89:349-354Goldman H, Ming S, Hickcock D. Nature and significance of hyperplastic polyps of the human colon. ArchPathol 1970:89:349-354Cooper H, Patchefsky A, Marks G. Adenomatous and carcinomatous changes within hyperplastic colonic epithelium. Dis Colon Rectum. 1979;22:152-156.Cooper H, Patchefsky A, Marks G. Adenomatous and carcinomatous changes within hyperplastic colonic epithelium. Dis Colon Rectum. 1979;22:152-156.Azimuddin К, etal. Hyperplastic polyps: "More than meets the eye"? Report of sixteen cases. Dis Colon Rectum 2000:43:1309-13Azimuddin К, etal. Hyperplastic polyps: "More than meets the eye"? Report of sixteen cases. Dis Colon Rectum 2000:43:1309-13Warner A.S, et al. Multiple large hyperplastic polyps of the colon coincident with adenocarcinoma. Am J Gastroenterol 1994;89:123-5Warner A.S, et al. Multiple large hyperplastic polyps of the colon coincident with adenocarcinoma. Am J Gastroenterol 1994;89:123-5Urbanski S, Marcon N, Kossakowska A, et al. Mixed hyperplastic adenomatous polyps: an underdiagnosed entity. Am J Surg Pathol. 1984;8:551-556Urbanski S, Marcon N, Kossakowska A, et al. Mixed hyperplastic adenomatous polyps: an underdiagnosed entity. Am J Surg Pathol. 1984;8:551-556Longacre T, Fenoglio-Preiser C. Mixed hyperplastic adenomatous polyps/serrated adenomas. Adistinctform of colorectal neoplasia. Am J SurgPathol. 1990;14:524-537Longacre T, Fenoglio-Preiser C. Mixed hyperplastic adenomatous polyps/serrated adenomas. Adistinctform of colorectal neoplasia. Am J SurgPathol. 1990;14:524-537Torlakovic E, Skovlund E, Snover D, et al. Morphologic reappraisal of serrated colorectal polyps. JSurgPathol. 2003;27:65-81Torlakovic E, Skovlund E, Snover D, et al. Morphologic reappraisal of serrated colorectal polyps. JSurgPathol. 2003;27:65-81Goldstein N.S, Bhanot P, Odish E, Hunter S. Hyperplastic-like colon polyps that preceded microsatellite-unstable adenocarcinomas. AmJCIinPathol. 2003; 119:778-796Goldstein N.S, Bhanot P, Odish E, Hunter S. Hyperplastic-like colon polyps that preceded microsatellite-unstable adenocarcinomas. AmJCIinPathol. 2003; 119:778-796Spring К J, Zhao Z Z, Karamatic R, et al. High prevalence of sessile serrated adenomas with В RAF mutations: a prospective study of patients undergoing colonoscopy. Gastroenterology, 2006:131:1400-1407Spring К J, Zhao Z Z, Karamatic R, et al. High prevalence of sessile serrated adenomas with В RAF mutations: a prospective study of patients undergoing colonoscopy. Gastroenterology, 2006:131:1400-1407Jass J, Smith M. Sialic acid and epithelial differentiation in colorectal polyps and cancer - a morphological, mucin and lectinhistochemical study. Pathology. 1992;24(4):233-42Jass J, Smith M. Sialic acid and epithelial differentiation in colorectal polyps and cancer - a morphological, mucin and lectinhistochemical study. Pathology. 1992;24(4):233-42Snover D.C, Ahnen D.J, Burt R.W, Odze R.D. Serrated polyps of the colon and rectum and serrated (“hyperplastic") polyposis. In: Bozman FT, Carneiro F, Hruban RH, Theise N, editors. WHO classification of tumours. Pathology and genetics. Tumours of the digestive system. Berlin: Springer-Verlag (4th ed. [in press])Snover D.C, Ahnen D.J, Burt R.W, Odze R.D. Serrated polyps of the colon and rectum and serrated (“hyperplastic") polyposis. In: Bozman FT, Carneiro F, Hruban RH, Theise N, editors. WHO classification of tumours. Pathology and genetics. Tumours of the digestive system. Berlin: Springer-Verlag (4th ed. [in press])Snover D.C. Update on the serrated pathway to colorectal carcinoma. Human Pathology, 2011; 42( 1): 1 - 10Snover D.C. Update on the serrated pathway to colorectal carcinoma. Human Pathology, 2011; 42( 1): 1 - 10M kinenMJ.Colorectalserratedadenocarcinoma.Histopathology, 2007;50:131-150M kinenMJ.Colorectalserratedadenocarcinoma.Histopathology, 2007;50:131-150Weston A.P, Campbell D.R. Diminutive colonic polyps: histopathology, spatial distribution, concomitant significant lesions, and treatment complications. Am. J. Gastroenterol. 1995; 90;24-28Weston A.P, Campbell D.R. Diminutive colonic polyps: histopathology, spatial distribution, concomitant significant lesions, and treatment complications. Am. J. Gastroenterol. 1995; 90;24-28M kinen M.J, George S.M, Jernvall P, Ma kela J, Vihko P, Karttunen T.J. Colorectal carcinoma associated with serrated adenoma- prevalence, histological features, and prognosis.J. Pathol. 2001; 193:286-294M kinen M.J, George S.M, Jernvall P, Ma kela J, Vihko P, Karttunen T.J. Colorectal carcinoma associated with serrated adenoma- prevalence, histological features, and prognosis.J. Pathol. 2001; 193:286-294Higuchi T, Sugihara K, Jass J.R. Demographic and pathological characteristics of serrated polyps of colorectum. Histopathology 2005; 47; 32-40Higuchi T, Sugihara K, Jass J.R. Demographic and pathological characteristics of serrated polyps of colorectum. Histopathology 2005; 47; 32-40Sweetser S., et al. Serrated Polyps Expert Rev Gastroenterol Hepatol. 2011 ;5(5):627-635Sweetser S., et al. Serrated Polyps Expert Rev Gastroenterol Hepatol. 2011 ;5(5):627-635Haws A.L Pathology of Serrated Colon Adenomas. Chief Editor: Mamoun Younes,2012http://emedicine. medscape.com/ article/1731536-overviewHaws A.L Pathology of Serrated Colon Adenomas. Chief Editor: Mamoun Younes,2012http://emedicine. medscape.com/ article/1731536-overviewНикишаев В.И., Патий А.Р, Тумак И.H., Коляда И.А. Эндоско-пическаядиагностикараннегоколоректальногьрака. Укра1нський журнал мапонвазивно таендоскоп1чно хирурги 2012; 16 (1):35-55Никишаев В.И., Патий А.Р, Тумак И.H., Коляда И.А. Эндоско-пическаядиагностикараннегоколоректальногьрака. Укра1нський журнал мапонвазивно таендоскоп1чно хирурги 2012; 16 (1):35-55Yang S, Farraye FA, Mack С, Posnik О, O'Brien MJ. BRAF and KRAS mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status. Am. J. Surg. Pathol. 2004; 28; 1452-1459Yang S, Farraye FA, Mack С, Posnik О, O'Brien MJ. BRAF and KRAS mutations in hyperplastic polyps and serrated adenomas of the colorectum: relationship to histology and CpG island methylation status. Am. J. Surg. Pathol. 2004; 28; 1452-1459O’Brien M.J, Yang S, Clebanoff J.L et al. Hyperplastic (serrated) polyps of the colorectum: relationship of CpG island methylator phenotype and K-ras mutation to location and histologic subtype. Am. J. Surg. Pathol. 2004; 28; 423-434O’Brien M.J, Yang S, Clebanoff J.L et al. Hyperplastic (serrated) polyps of the colorectum: relationship of CpG island methylator phenotype and K-ras mutation to location and histologic subtype. Am. J. Surg. Pathol. 2004; 28; 423-434Lee E.J, Choi C, Park C.K et al. Tracing origin of serrated adenomas with BRAF and KRAS mutations. VirchowsArch.2005; 447:597-602Lee E.J, Choi C, Park C.K et al. Tracing origin of serrated adenomas with BRAF and KRAS mutations. VirchowsArch.2005; 447:597-602Goldstein N.S. Clinical significance of (sessile) serrated adenomas: another piece of the puzzle. Am. J. Clin. Pathol. 2005; 123; 329330Goldstein N.S. Clinical significance of (sessile) serrated adenomas: another piece of the puzzle. Am. J. Clin. Pathol. 2005; 123; 329330Goldstein N.S. Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases. Am. J.CIin. Pathol. 2006; 125; 132-145Goldstein N.S. Small colonic microsatellite unstable adenocarcinomas and high-grade epithelial dysplasias in sessile serrated adenoma polypectomy specimens: a study of eight cases. Am. J.CIin. Pathol. 2006; 125; 132-145Carr N.J, Mahajan H, Tan K.L, Hawkins N.J, Ward R.L. Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma. J. Clin. Pathol. 2009:62: 516-518Carr N.J, Mahajan H, Tan K.L, Hawkins N.J, Ward R.L. Serrated and non-serrated polyps of the colorectum: their prevalence in an unselected case series and correlation of BRAF mutation analysis with the diagnosis of sessile serrated adenoma. J. Clin. Pathol. 2009:62: 516-518Chandra A, Sheikh A, Cerar A, et al. Clinico-pathological aspects of colorectal serrated adenomas. World J Gastroenterol. 2006; 12( 11)2770-2172Chandra A, Sheikh A, Cerar A, et al. Clinico-pathological aspects of colorectal serrated adenomas. World J Gastroenterol. 2006; 12( 11)2770-2172Snover D.C, Jass J.R, Fenoglio-Preiser C, Batts K.P. Serrated polyps of the large intestine: a morphologic and molecular review of an evolving concept. AmJCIinPathol. 2005;124(3):380-91Snover D.C, Jass J.R, Fenoglio-Preiser C, Batts K.P. Serrated polyps of the large intestine: a morphologic and molecular review of an evolving concept. AmJCIinPathol. 2005;124(3):380-91Iwabuchi M, Sasano H, Hiwatashi N, et al. Serrated adenoma: a clinicopathological DNA ploidy, and immunohistochemical study. Anticancer Res. 2000;20:1141 -1147Iwabuchi M, Sasano H, Hiwatashi N, et al. Serrated adenoma: a clinicopathological DNA ploidy, and immunohistochemical study. Anticancer Res. 2000;20:1141 -1147Rex D.K, Rahmani E.Y. New endoscopic finding associated with hyperplastic polyps. Gastrointest. Endosc. 1999; 50; 704-706Rex D.K, Rahmani E.Y. New endoscopic finding associated with hyperplastic polyps. Gastrointest. Endosc. 1999; 50; 704-706Oka S, Tanaka S, Hiyama T et al. Clinicopathologic and endoscopic features of colorectal serrated adenoma: differences between polypoid and superficial types. Gastrointest. Endosc.2004; 59; 213-2.1.9Oka S, Tanaka S, Hiyama T et al. Clinicopathologic and endoscopic features of colorectal serrated adenoma: differences between polypoid and superficial types. Gastrointest. Endosc.2004; 59; 213-2.1.9Jaramillo E, Tamura S, Mitomi H. Endoscopic appearance of serrated adenomas in the colon. Endoscopy. 2005:37:254-260Jaramillo E, Tamura S, Mitomi H. Endoscopic appearance of serrated adenomas in the colon. Endoscopy. 2005:37:254-260Morita T, Tamura S, Miyazaki J, Higashidani Y, Onishi S. Evaluation of endoscopic and histopathological features of serrated adenoma of the colon. Endoscopy 2001; 33; 761-765Morita T, Tamura S, Miyazaki J, Higashidani Y, Onishi S. Evaluation of endoscopic and histopathological features of serrated adenoma of the colon. Endoscopy 2001; 33; 761-765Higuchi T, Jass J.R. My approach to serrated polyps of the colorectum. J. Clin. Pathol. 2004; 57; 682-686Higuchi T, Jass J.R. My approach to serrated polyps of the colorectum. J. Clin. Pathol. 2004; 57; 682-686Torlakovic E, Skovlund E, Snover D.C, Torlakovic G, Nesland JM. Morphologic reappraisal of serrated colorectal polyps. Am. J. Surg. Pathol. 2003; 27; 65-81Torlakovic E, Skovlund E, Snover D.C, Torlakovic G, Nesland JM. Morphologic reappraisal of serrated colorectal polyps. Am. J. Surg. Pathol. 2003; 27; 65-81Rex D.K, Ahnen D.J, Baron J.A, et al. Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel. The American Journal of Gastroenterology. 2012; 107:13151329Rex D.K, Ahnen D.J, Baron J.A, et al. Serrated Lesions of the Colorectum: Review and Recommendations From an Expert Panel. The American Journal of Gastroenterology. 2012; 107:13151329Groff R.J, Nash R, Ahnen D.J. Significance of serrated polyps of the colon. Current Gastroenterol. 2008; 10:490-498Groff R.J, Nash R, Ahnen D.J. Significance of serrated polyps of the colon. Current Gastroenterol. 2008; 10:490-498Leggett B, Whitehall V. Role of the serrated pathway in colorectal cancer pathogenesis. Gastroenterology 2010; 138:2088-2100Leggett B, Whitehall V. Role of the serrated pathway in colorectal cancer pathogenesis. Gastroenterology 2010; 138:2088-2100Li SC, Burgart L. Histopathology of serrated adenoma, its variants, and differentiation from conventional adenomatous and hyperplastic polyps. Arch. Pathol. Lab. Med. 2007;131:440-445Li SC, Burgart L. Histopathology of serrated adenoma, its variants, and differentiation from conventional adenomatous and hyperplastic polyps. Arch. Pathol. Lab. Med. 2007;131:440-445Bariol C, Hawkins N.J, Turner J.J, Meagher A.P, Williams D.B, Ward R.L. Histopathological and clinical evaluation of serrated adenomas of the colon and rectum. Mod. Pathol. 2003; 16:417-423Bariol C, Hawkins N.J, Turner J.J, Meagher A.P, Williams D.B, Ward R.L. Histopathological and clinical evaluation of serrated adenomas of the colon and rectum. Mod. Pathol. 2003; 16:417-423Higuchi T, Sugihara K, Jass J.R. Demographic and pathological characteristics of serrated polyps of colorectum. Histopathology 2005; 47; 32-40Higuchi T, Sugihara K, Jass J.R. Demographic and pathological characteristics of serrated polyps of colorectum. Histopathology 2005; 47; 32-40Jaramillo E, Watanabe M, Rubio C, Slezak P. Small colorectal serrated adenomas: endoscopic findings. Endoscopy. 1997;29(1): 1-3Jaramillo E, Watanabe M, Rubio C, Slezak P. Small colorectal serrated adenomas: endoscopic findings. Endoscopy. 1997;29(1): 1-3Lazarus R, Junttila O.E, Karttunen T.J, Makinen M.J. The risk of metachronousneoplasia in patients with serrated adenoma. AmJCIinPathol. Mar 2005;123(3):349-59Lazarus R, Junttila O.E, Karttunen T.J, Makinen M.J. The risk of metachronousneoplasia in patients with serrated adenoma. AmJCIinPathol. Mar 2005;123(3):349-59Matsumoto T, Mizuno M, Shimizu M, Manabe T, lida M, Fujishima M. Serrated adenoma of the colorectum: colonoscopic and histologic features. Gastrointest. Endosc. 1999; 49; 736-742Matsumoto T, Mizuno M, Shimizu M, Manabe T, lida M, Fujishima M. Serrated adenoma of the colorectum: colonoscopic and histologic features. Gastrointest. Endosc. 1999; 49; 736-742Matsumoto T, Mizuno M, Shimizu M, Manabe T, lida M. Clinicopathological features of serrated adenoma of the colorectum: comparison with traditional adenoma. J ClinPathol. 1999;52(7):513-6Matsumoto T, Mizuno M, Shimizu M, Manabe T, lida M. Clinicopathological features of serrated adenoma of the colorectum: comparison with traditional adenoma. J ClinPathol. 1999;52(7):513-6The Paris endoscopic classification of superficial neoplastic lesions (2003) Gastrointest. Endosc. 58;6:3-43The Paris endoscopic classification of superficial neoplastic lesions (2003) Gastrointest. Endosc. 58;6:3-43DiSario J.A, Foutch P.G, Mai H.D, Pardy K, Manne R.K. Prevalence and malignant potential of colorectal polyps in asymptomatic, average-risk men. AmJGastroenterol. 1991;86(8):941-5DiSario J.A, Foutch P.G, Mai H.D, Pardy K, Manne R.K. Prevalence and malignant potential of colorectal polyps in asymptomatic, average-risk men. AmJGastroenterol. 1991;86(8):941-5Ladas S.D, Kitsanta P, Triantafyllou K, Tzathas C, Spiliadi C, Raptis SA. Cell turnover of serrated adenomas. J. Pathol. 2005;206; 62-67Ladas S.D, Kitsanta P, Triantafyllou K, Tzathas C, Spiliadi C, Raptis SA. Cell turnover of serrated adenomas. J. Pathol. 2005;206; 62-67Ho rkko T.T, M kinen M.J. Colorectal proliferation and apoptosis in serrated versus conventional adenoma-carcinoma pathway: growth, progression and survival. Scand. J. Gastroenterol. 2003; 38;1241-1248Ho rkko T.T, M kinen M.J. Colorectal proliferation and apoptosis in serrated versus conventional adenoma-carcinoma pathway: growth, progression and survival. Scand. J. Gastroenterol. 2003; 38;1241-1248Farris AB, Misdraji J, Srivastava A, etal. Sessile serrated adenoma: challenging discrimination from other serrated colonic polyps. Am J SurgPathol. 2008;32(1):30-5Farris AB, Misdraji J, Srivastava A, etal. Sessile serrated adenoma: challenging discrimination from other serrated colonic polyps. Am J SurgPathol. 2008;32(1):30-5Bustamante-Balen M, Bernet L, Cano R, Morell L, Lopez A. Assessing the reproducibility of the microscopic diagnosis of sessile serrated adenoma of the colon. Rev EspEnferm Dig. 2009;101(4):258-64Bustamante-Balen M, Bernet L, Cano R, Morell L, Lopez A. Assessing the reproducibility of the microscopic diagnosis of sessile serrated adenoma of the colon. Rev EspEnferm Dig. 2009;101(4):258-64Hawkins N, et al. CpG island methylation in sporadic colorectal cancer and its relationship to microsatellite instability. Gastroenterology 2002; 122:1376-87Hawkins N, et al. CpG island methylation in sporadic colorectal cancer and its relationship to microsatellite instability. Gastroenterology 2002; 122:1376-87Wang L.R Chen J, Ning H.Y, Zhang X.Z, Cheng J, Li L, Wang B, Dai X.J, Zhu H.Y, Miao J.H, Wang L. Serrated lesions of colon and their malignant potential. Zhonghua Bing Li XueZaZhi. 2010;39(7):447-51Wang L.R Chen J, Ning H.Y, Zhang X.Z, Cheng J, Li L, Wang B, Dai X.J, Zhu H.Y, Miao J.H, Wang L. Serrated lesions of colon and their malignant potential. Zhonghua Bing Li XueZaZhi. 2010;39(7):447-51
The authors declare that there are no conflicts of interest present.