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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinendo</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая эндоскопия</journal-title><trans-title-group xml:lang="en"><trans-title>Filin’s Clinical endoscopy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2415-7813</issn><publisher><publisher-name>"Global Media technology" Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/2415-7813-endo-66-4-62-65</article-id><article-id custom-type="elpub" pub-id-type="custom">clinendo-191</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group></article-categories><title-group><article-title>Клинические наблюдения эндоскопической диагностики и лечения лейкоплакии пищевода</article-title><trans-title-group xml:lang="en"><trans-title>Endoscopic diagnosis and treatment of esophageal leukoplakia: clinical case</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1746-0583</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гагаев</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gagaev</surname><given-names>R. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8101-2155</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пирогов</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Pirogov</surname><given-names>S. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1028-6308</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смирнова</surname><given-names>Р. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Smirnova</surname><given-names>R. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3039-1431</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Евсеева</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Evseeva</surname><given-names>Yu. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0223-0753</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гамаюнов</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gamayunov</surname><given-names>S. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8784-8415</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каприн</surname><given-names>А. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Kaprin</surname><given-names>A. D.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГАУЗ НО «НИИКО «Нижегородский Областной Клинический Онкологический Диспансер»</institution></aff><aff xml:lang="en"><institution>Nizhny Novgorod Regional Clinical Oncological Dispensary</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>МНИОИ им. П. А. Герцена - филиал ФГБУ «НМИЦ радиологии» Минздрава России</institution></aff><aff xml:lang="en"><institution>P.A. Herzen Moscow Cancer Research Institute, branch of National Medical Research Radiology Center</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГАУЗ НО «НИИКО «Нижегородский Областной Клинический Онкологический Диспансер»; МРНЦ им А. Ф. Цыба - филиал НМИЦ Радиологии Минздрава России</institution></aff><aff xml:lang="en"><institution>Nizhny Novgorod Regional Clinical Oncological Dispensary; A.F. Tsyba MRSC, branch of National Medical Research Radiology Center</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>06</day><month>03</month><year>2025</year></pub-date><volume>66</volume><issue>4</issue><fpage>62</fpage><lpage>65</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гагаев Р.А., Пирогов С.С., Смирнова Р.С., Евсеева Ю.А., Гамаюнов С.В., Каприн А.Д., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Гагаев Р.А., Пирогов С.С., Смирнова Р.С., Евсеева Ю.А., Гамаюнов С.В., Каприн А.Д.</copyright-holder><copyright-holder xml:lang="en">Gagaev R.A., Pirogov S.S., Smirnova R.S., Evseeva Y.A., Gamayunov S.V., Kaprin A.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://clinendo.elpub.ru/jour/article/view/191">https://clinendo.elpub.ru/jour/article/view/191</self-uri><abstract><p>Лейкоплакия пищевода является чрезвычайно редким патологическим состоянием слизистой оболочки пищевода, обладающим высоким потенциалом малигнизации. В настоящее время отсутствуют общепринятые рекомендации по лечению пациентов с диагнозом «лейкоплакия пищевода». Однако, современные эндоскопические технологии позволяют не только с высокой точностью диагностировать это заболевание, но и выполнять радикальное органосохраняющее лечение. Данное клиническое наблюдение демонстрирует результаты эндоскопической диагностики лейкоплакии пищевода и вариант оперативного лечения путем аргоно-плазменной деструкции.</p></abstract><trans-abstract xml:lang="en"><p>Esophageal leukoplakia is an extremely rare pathological condition of the esophageal mucosa and, at the same time, a lesion that has a high potential for malignization. Currently, there are no generally accepted recommendations for the treatment of patients diagnosed with leukoplakia. However, modern endoscopic techniques allows not only to diagnose this pathology with high accuracy, but also is one of the methods of radical treatment. This clinical observation demonstrates the results of endoscopic diagnosis of esophageal leukoplakia and the option of surgical treatment by argon-plasma coagulation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>эзофагогастродуоденоскопия</kwd><kwd>узкоспектральная эндоскопия</kwd><kwd>лейкоплакия</kwd><kwd>NBI</kwd><kwd>BLI</kwd><kwd>аргоноплазменная коагуляция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Upper GI endoscopy</kwd><kwd>Leukoplakia</kwd><kwd>Narrow-band imaging</kwd><kwd>NBI</kwd><kwd>BLI</kwd><kwd>argon-plasma coagulation</kwd><kwd>Dual Focus</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Singhi A. D., Arnold C. A., Lam-Himlin D. M. et al. Targeted next-generation sequencing supports epidermoid metaplasia of the esophagus as a precursor to esophageal squamous neoplasia. 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