clinendoКлиническая эндоскопияFilin’s Clinical endoscopy2415-7813"Global Media technology" Ltd10.31146/2415-7813-endo-66-4-41-53clinendo-189Research ArticleДЕТСКАЯ ЭНДОСКОПИЯPEDIATRIC ENDOSCOPYКонфокальная лазерная эндомикроскопия пищеварительного тракта у детейConfocal laser endomicroscopy of the digestive tract in childrenШавровА. А.ShavrovA. A.shavrovnczd@yandex.ruВолынецГ. В.VolynetsG. V.noemail@neicon.ruШавровА. А.ShavrovA. A.noemail@neicon.ruМорозовД. А.MorozovD. A.noemail@neicon.ruХаритоновА. Ю.KharitonovaA. Yu.noemail@neicon.ruФГАОУ ВО Первый МГМУ им. И. М. Сеченова Минздрава РоссииI. M. Sechenov First Moscow State Medical UniversityНИКИ педиатрии и детской хирургии им. Ю. Е. ВельтищеваY. E. Veltischev Research and Clinical Institute for Pediatrics and Pediatric SurgeryНИИ Неотложной детской хирургии и травматологии ДЗ г. Москвы; РНИМУ им. Н. И. Пирогова Минздрава РоссииClinical and Research Institute of Emergency Pediatric Surgery and Trauma; Russian National Research Medical University named after N. I. PirogovФГАОУ ВО Первый МГМУ им. И. М. Сеченова Минздрава России; НИКИ педиатрии и детской хирургии им. Ю. Е. ВельтищеваI. M. Sechenov First Moscow State Medical University; Y. E. Veltischev Research and Clinical Institute for Pediatrics and Pediatric SurgeryНИИ Неотложной детской хирургии и травматологии ДЗ г. МосквыClinical and Research Institute of Emergency Pediatric Surgery and Trauma2024060320256644153Copyright © Шавров А.А., Волынец Г.В., Шавров А.А., Морозов Д.А., Харитонов А.Ю., 20252025Шавров А.А., Волынец Г.В., Шавров А.А., Морозов Д.А., Харитонов А.Ю.Shavrov A.A., Volynets G.V., Shavrov A.A., Morozov D.A., Kharitonova A.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://clinendo.elpub.ru/jour/article/view/189

В обзоре современной литературы описаны история развития, принцип, методика и клиническое применение конфокальной лазерной эндомикроскопии у детей. Реализация данной технологии позволяет не только дополнить и расширить возможности диагностики с помощью традиционных внутрипросветных методов исследования, но и определять эффективность лечебных мероприятий различных болезней пищеварительного тракта. Представлены новые экспериментальные и клинические данные диагностического применения конфокальной лазерной эндомикроскопии в оценке воспалительных изменений пищеварительного тракта, барьерной функции тонкой и подвздошной кишки как предиктора обострения патологического процесса при воспалительных заболеваниях кишечника, применении технологии при синдроме раздраженного кишечника и болезни Гиршпрунга. Приведены примеры научных исследований у взрослых пациентов, которые потенциально могут быть крайне полезны и у педиатрических больных. Обсуждаются проблемы связанные с использованием технологии оптической биопсии органов пищеварительного тракта и перспективы ее применения в педиатрической практике.

In this review article briefly described history, principles, technique and clinical applications of confocal laser endomicroscopy. This technology allows to expand the diagnostic ability of traditional white light endoscopy and to assess effectiveness of therapeutic procedures in different gastrointestinal diseases. New experimental and clinical data in assessing inflammatory changes of the digestive tract, small bowel barrier dysfunction as a predictor of relapse for inflammatory bowel disease, applying of the technology in irritable bowel syndrome and Hirschsprung disease is presented. Examples of reports in adult patients are given, which can potentially be extremely useful in pediatric patients. Problems and perspectives regarding application of optical biopsy for gastrointestinal tract in pediatric practice are discussed.

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The authors declare that there are no conflicts of interest present.