<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">clinendo</journal-id><journal-title-group><journal-title xml:lang="ru">Клиническая эндоскопия</journal-title><trans-title-group xml:lang="en"><trans-title>Filin’s Clinical endoscopy</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2415-7813</issn><publisher><publisher-name>"Global Media technology" Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.31146/2415-7813-endo-64-3-48-55</article-id><article-id custom-type="elpub" pub-id-type="custom">clinendo-106</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ГАСТРОЭНТЕРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>GASTROENTEROLOGY</subject></subj-group></article-categories><title-group><article-title>Особенности лечебной тактики при некоторых клинико-патогенетических вариантах гастроэзофагеальной рефлюксной болезни</article-title><trans-title-group xml:lang="en"><trans-title>Features of treatment tactics for some clinical and pathogenetic variants of gastroesophageal reflux disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новиков</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Novikov</surname><given-names>V. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сандрацкая</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sandratskaya</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванюк</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanyuk</surname><given-names>A. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яковлева</surname><given-names>Э. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Yakovleva</surname><given-names>E. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Пермский клинический центр Федерального медико-биологического агентства России</institution></aff><aff xml:lang="en"><institution>Perm Clinical Centre of the Federal Medical and Biological Agency of Russia</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Военно-медицинская академия им. С.М. Кирова Минобороны России</institution></aff><aff xml:lang="en"><institution>S.M. Kirov Military Medical Academy of the Ministry of Defence of Russia</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>25</day><month>09</month><year>2024</year></pub-date><volume>64</volume><issue>3</issue><fpage>48</fpage><lpage>55</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Новиков В.Н., Сандрацкая А.В., Иванюк А.С., Яковлева Э.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Новиков В.Н., Сандрацкая А.В., Иванюк А.С., Яковлева Э.В.</copyright-holder><copyright-holder xml:lang="en">Novikov V.N., Sandratskaya A.V., Ivanyuk A.S., Yakovleva E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://clinendo.elpub.ru/jour/article/view/106">https://clinendo.elpub.ru/jour/article/view/106</self-uri><abstract><p>Актуальность Гастроэзофагеальная рефлюксная болезнь - заболевание, которое имеет сложный механизм формирования, обуславливающий многообразие клинических и патогенетических особенностей, реализуемых в процессе развития патологического процесса. Из этого посыла формируется и многообразие тактических и методологических решений при ее лечении. Материал и методы 25 летний опыт авторов, который заключается в непосредственном участие в диагностическом и лечебном процессе у нескольких тысяч пациентов с гастроэзофагеальным рефлюксом, в числе которых несколько сотен больных с цилиндроклеточной метаплазией и пищеводом Барретта. Результат Определение показаний к хирургическому лечение осложненной и неосложненной гастроэзофагеальной рефлюксной болезни является сложным и ответственным решением. Для определения показаний к коррекции и хирургической тактики необходимо учитывать: характер и выраженность цилиндроклеточной метаплазии, величину аксиальной грыжи и ее сочетание с недостаточностью кардиального жома, выраженность недостаточности жома и сохранность диафрагмального сужения, состояние угла Гиса, тип и выраженность рефлюкс-эзофагита, а также наличие необратимых изменений слизистой оболочки. Необходимо обращать внимание на тяжесть клинических проявлений заболевания.</p></abstract><trans-abstract xml:lang="en"><p>Relevance Gastroesophageal reflux disease is a disease that has a complex mechanism of formation, causing a variety of clinical and pathogenetic features, realised during the development of the pathological process. The variety of tactical and methodological solutions in its treatment is formed from this premise. Material and Methods The authors have 25 years of experience, which consists in direct participation in the diagnostic and therapeutic process in several thousand patients with gastroesophageal reflux, including several hundred patients with cylindrocellular metaplasia and Barrett’s oesophagus. Results Determination of indications for surgical treatment of complicated and uncomplicated gastroesophageal reflux disease is a complex and responsible decision. It is necessary to take into account: the nature and severity of cylindrocellular metaplasia, the size of axial hernia and its combination with insufficiency of cardiac jejunum, the severity of jejunal insufficiency and preservation of diaphragmatic constriction, the state of Gis angle, the type and severity of reflux - esophagitis, as well as the presence of irreversible changes in the mucosa to determine the indications for correction and surgical tactics. It is necessary to pay attention to the severity of clinical manifestations of the disease.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гастроэзофагеальная рефлюксная болезнь</kwd><kwd>цилиндроклеточная метаплазия</kwd><kwd>аксиальная грыжа</kwd><kwd>недосточность кардиального жома</kwd><kwd>рефлюкс-эзофагит</kwd></kwd-group><kwd-group xml:lang="en"><kwd>gastroesophageal reflux disease</kwd><kwd>cylindrocellular metaplasia</kwd><kwd>axial hernia</kwd><kwd>cardiac jejunum undersaturation</kwd><kwd>reflux - esophagitis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Vologzhanina L. G. Clinical and functional features of duodenal ulcer, occurring in combination with gastroesophageal reflux disease, and evaluation of the effectiveness of its complex treatment. Dis. … med. science. Moscow. 2020; 104 P. (in Russ.)@@ Вологжанина Л. Г. Клинико - функциональные особенности язвенной болезни двенадцатиперстной кишки, протекающей в сочетании с гастроэзофагеальной рефлюксной болезнью, и оценка эффективности её комплексного лечения. Дис. … канд. мед. наук. Пермь, 2006; 222 с.</mixed-citation><mixed-citation xml:lang="en">Vologzhanina L. G. Clinical and functional features of duodenal ulcer, occurring in combination with gastroesophageal reflux disease, and evaluation of the effectiveness of its complex treatment. Dis. … med. science. Moscow. 2020; 104 P. (in Russ.)@@ Вологжанина Л. Г. Клинико - функциональные особенности язвенной болезни двенадцатиперстной кишки, протекающей в сочетании с гастроэзофагеальной рефлюксной болезнью, и оценка эффективности её комплексного лечения. Дис. … канд. мед. наук. Пермь, 2006; 222 с.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ivanyuk A. S. Features of the diagnosis of gastroesophageal reflux disease and endosurgical treatment of uncomplicated and complicated forms of it. Avtoref. dis. … med. science. Perm., 2011; 23 P. (in Russ.)@@ Иванюк А. С. Особенности диагностики гастроэзофагеальнои рефлюкснои болезни и эндохирургическое лечение неосложнённых и осложненных её форм. Автореф. дис. … канд. мед. наук. Пермь, 2011; 23 с.</mixed-citation><mixed-citation xml:lang="en">Ivanyuk A. S. Features of the diagnosis of gastroesophageal reflux disease and endosurgical treatment of uncomplicated and complicated forms of it. Avtoref. dis. … med. science. Perm., 2011; 23 P. (in Russ.)@@ Иванюк А. С. Особенности диагностики гастроэзофагеальнои рефлюкснои болезни и эндохирургическое лечение неосложнённых и осложненных её форм. Автореф. дис. … канд. мед. наук. Пермь, 2011; 23 с.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Kornyak B. S. Gastroesophageal reflux disease. Diagnosis and surgical treatment. Avtoref. dis. … med. science. Moscow, 2001; 47 P. (in Russ.)@@ Корняк Б. С. Гастроэзофагеальная рефлюксная болезнь. Диагностика и хирургическое лечение. Автореф. дис… д-ра мед. наук. М., 2001. 47 c.</mixed-citation><mixed-citation xml:lang="en">Kornyak B. S. Gastroesophageal reflux disease. Diagnosis and surgical treatment. Avtoref. dis. … med. science. Moscow, 2001; 47 P. (in Russ.)@@ Корняк Б. С. Гастроэзофагеальная рефлюксная болезнь. Диагностика и хирургическое лечение. Автореф. дис… д-ра мед. наук. М., 2001. 47 c.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Kornyak B. S., Kochatkov A. V. Failures of antireflux surgery. Indications for repeated operations and treatment results. Endoscope. Surg. 2004; 2: 4-11. (in Russ.)@@ Корняк Б. С., Кочатков А. В. Неудачи антирефлюксной хирургии. Показания к повторным операциям и результаты лечения. Эндоскоп. хир. 2004; 2: 4-11.</mixed-citation><mixed-citation xml:lang="en">Kornyak B. S., Kochatkov A. V. Failures of antireflux surgery. Indications for repeated operations and treatment results. Endoscope. Surg. 2004; 2: 4-11. (in Russ.)@@ Корняк Б. С., Кочатков А. В. Неудачи антирефлюксной хирургии. Показания к повторным операциям и результаты лечения. Эндоскоп. хир. 2004; 2: 4-11.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Puchkov K. V., Filimonov V. B. Hernias of the esophageal orifice of the diaphragm. M: Medpraktika, 2003; 172 P. (in Russ.)@@ Пучков К. В., Филимонов В. Б. Грыжи пищеводного отверстия диафрагмы. М: Медпрактика, 2003; 172 с.</mixed-citation><mixed-citation xml:lang="en">Puchkov K. V., Filimonov V. B. Hernias of the esophageal orifice of the diaphragm. M: Medpraktika, 2003; 172 P. (in Russ.)@@ Пучков К. В., Филимонов В. Б. Грыжи пищеводного отверстия диафрагмы. М: Медпрактика, 2003; 172 с.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Trukhmanov A. S. Gastroesophageal reflux disease: clinical options, prognosis, treatment. Avtoref. diss. … med. science. Moscow. 2008; 41P. (in Russ.)@@ Трухманов А. С. Гастроэзофагеальная рефлюксная болезнь: клинические варианты, прогноз, лечение. Автореф. дис. … д-ра мед. наук. М., 2008; 41 с.</mixed-citation><mixed-citation xml:lang="en">Trukhmanov A. S. Gastroesophageal reflux disease: clinical options, prognosis, treatment. Avtoref. diss. … med. science. Moscow. 2008; 41P. (in Russ.)@@ Трухманов А. С. Гастроэзофагеальная рефлюксная болезнь: клинические варианты, прогноз, лечение. Автореф. дис. … д-ра мед. наук. М., 2008; 41 с.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Chernousov F. A., Shestakov A. L., Egorova L. K. The results of fundoplications in the treatment of reflux esophagitis. Bull. Surg. Gastroenter. 2009; 4: 64-69 (in Russ.)@@ Черноусов Ф. А., Шестаков А. Л., Егорова Л. К. Результаты фундопликаций при лечении рефлюксэзофагита. Вест. хир. гастроэнтер. 2009; 4: 64-69.</mixed-citation><mixed-citation xml:lang="en">Chernousov F. A., Shestakov A. L., Egorova L. K. The results of fundoplications in the treatment of reflux esophagitis. Bull. Surg. Gastroenter. 2009; 4: 64-69 (in Russ.)@@ Черноусов Ф. А., Шестаков А. Л., Егорова Л. К. Результаты фундопликаций при лечении рефлюксэзофагита. Вест. хир. гастроэнтер. 2009; 4: 64-69.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">American Gastroenterological Association Medical Position Statement on the Management of Gasroesophageal Reflux Disease. Gastroenterology 2008; 135: 1383-1391. doi: 10.1053/j.gastro.2008.08.045.</mixed-citation><mixed-citation xml:lang="en">American Gastroenterological Association Medical Position Statement on the Management of Gasroesophageal Reflux Disease. Gastroenterology 2008; 135: 1383-1391. doi: 10.1053/j.gastro.2008.08.045.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Chrysos E., Tsiaoussis J., Zoras O. J. et al. Laparoscopic Surgery for Gastroesophageal Reflux Disease in Patients With Impaired Esophageal Peristalsis: Total or Partial Fundoplication? J. Am. Coll. Surg. 2003; 197: 8-15. doi: 10.1016/S1072-7515(03)00151-0.</mixed-citation><mixed-citation xml:lang="en">Chrysos E., Tsiaoussis J., Zoras O. J. et al. Laparoscopic Surgery for Gastroesophageal Reflux Disease in Patients With Impaired Esophageal Peristalsis: Total or Partial Fundoplication? J. Am. Coll. Surg. 2003; 197: 8-15. doi: 10.1016/S1072-7515(03)00151-0.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Draaisma W. A., Rijnhart-de Jong H. G., Breeders L. A. et al. Five-year subjective and objective results of laparoscopic and conventional Nissen fundoplication: a randomized trial. Ann. Surg. 2006; 244: 34-41. doi: 10.1097/01.sla.0000217667.55939.64.</mixed-citation><mixed-citation xml:lang="en">Draaisma W. A., Rijnhart-de Jong H. G., Breeders L. A. et al. Five-year subjective and objective results of laparoscopic and conventional Nissen fundoplication: a randomized trial. Ann. Surg. 2006; 244: 34-41. doi: 10.1097/01.sla.0000217667.55939.64.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Erenoglu С., Miller A., Schirmer B. Laparoscopic Toupet versus Nissen fundoplication for the treatment of gastroesophageal reflux disease. Int. Surg. 2003; 88 (4): 219-225. PMID: 14717528.</mixed-citation><mixed-citation xml:lang="en">Erenoglu С., Miller A., Schirmer B. Laparoscopic Toupet versus Nissen fundoplication for the treatment of gastroesophageal reflux disease. Int. Surg. 2003; 88 (4): 219-225. PMID: 14717528.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Furnee E. J.B., Draaisma W. A., Breeders L. A. et al. Gooszen Surgical Reintervention After Failed Antireflux Surgery: A Systematic Review of the Literature. J. Gastrointest. Surg. 2009; 13(8): 1539-1549. doi: 10.1007/s11605-009-0873- z.</mixed-citation><mixed-citation xml:lang="en">Furnee E. J.B., Draaisma W. A., Breeders L. A. et al. Gooszen Surgical Reintervention After Failed Antireflux Surgery: A Systematic Review of the Literature. J. Gastrointest. Surg. 2009; 13(8): 1539-1549. doi: 10.1007/s11605-009-0873- z.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Holscher A. H., Bollschweiler E., Gutschow С. GERD and Complications: When is Surgery Necessary? Gastroenterol. 2007; 45 (11): 1150-1155. doi: 10.1055 /s-2007-963630.</mixed-citation><mixed-citation xml:lang="en">Holscher A. H., Bollschweiler E., Gutschow С. GERD and Complications: When is Surgery Necessary? Gastroenterol. 2007; 45 (11): 1150-1155. doi: 10.1055 /s-2007-963630.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Rossi M., Barreca M., de Bortoli N. et al. Efficacy of Nissen fundoplication versus medical therapy in the regression of low grade dysplasia in patients with Barrett esophagus. Ann. Surg. 2006; 243: 58-63. doi: 10.1097/01.sla.0000194085.56699.db.</mixed-citation><mixed-citation xml:lang="en">Rossi M., Barreca M., de Bortoli N. et al. Efficacy of Nissen fundoplication versus medical therapy in the regression of low grade dysplasia in patients with Barrett esophagus. Ann. Surg. 2006; 243: 58-63. doi: 10.1097/01.sla.0000194085.56699.db.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Van Herwaarden M. A. Excess gastroesophageal reflux in patients with hiatus hernia is caused by mechanisms other then transient LES relaxations. Gastroenterology. 2000; 12: 614-619. doi: 10.1053/GAST.2000.20191.</mixed-citation><mixed-citation xml:lang="en">Van Herwaarden M. A. Excess gastroesophageal reflux in patients with hiatus hernia is caused by mechanisms other then transient LES relaxations. Gastroenterology. 2000; 12: 614-619. doi: 10.1053/GAST.2000.20191.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Wykypiel H., Gadenstaetter M., Klaus A. et al. Nissen or partial posterior fiindoplication: which antireflux procedure has a lower rate of side effects? Arch. Surg. 2005; 390 (2): 141-147. doi: 10.1007 /s00423-004-0537-0.</mixed-citation><mixed-citation xml:lang="en">Wykypiel H., Gadenstaetter M., Klaus A. et al. Nissen or partial posterior fiindoplication: which antireflux procedure has a lower rate of side effects? Arch. Surg. 2005; 390 (2): 141-147. doi: 10.1007 /s00423-004-0537-0.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
